diff --git a/README.md b/README.md
index ae67d4e..dabf5ae 100644
--- a/README.md
+++ b/README.md
@@ -389,6 +389,15 @@ cp oravector-demo/backend/.env.example oravector-demo/backend/.env
 
 ## Setup from scratch
 
+### 0. Python dependencies
+
+Install all required packages for both backends:
+
+```bash
+pip3 install -r pgvector-demo/backend/requirements.txt --break-system-packages
+pip3 install -r oravector-demo/backend/requirements.txt --break-system-packages
+```
+
 ### 1. PostgreSQL
 
 **Start the container:**